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Re-examination of the “3/4-law” of metabolism

P. S. Dodds, D. H. Rothman, and J. S. Weitz

Journal of Theoretical Biology, 2001

Times cited: 694

Abstract:

We examine the scaling law $B=cM^{\alpha}$ which connects organismal resting metabolic rate $B$ with organismal mass $M$, where $\alpha$ is commonly held to be 3/4. Since simple dimensional analysis suggests $\alpha=2/3$, we consider this to be a null hypothesis testable by empirical studies. We re-analyze data sets for mammals and birds compiled by Heusner, Bennett and Harvey, Bartels, Hemmingsen, Brody, and Kleiber, and find little evidence for rejecting $\alpha=2/3$ in favor of $\alpha=3/4$. For mammals, we find a possible breakdown in scaling for larger masses reflected in a systematic increase in $\alpha$. We also review theoretical justifications of $\alpha=3/4$ based on dimensional analysis, nutrient-supply networks, and four-dimensional biology. We find that present theories for $\alpha=3/4$ require assumptions that render them unconvincing for rejecting the null hypothesis that $\alpha=2/3$.
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BibTeX:

@Article{dodds2001d,
  author = 	 {Dodds, Peter Sheridan and Rothman, Daniel H. and Weitz, Joshua S.},
  title = 	 {Re-examination of the "3/4-law" of metabolism},
  journal =      {Journal of Theoretical Biology},
  year = 	 {2001},
  key =          {biology},
  volume =       {209},
  pages =        {9–27},
}

 

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