Re-examination of the '3/4-law' of metabolism
P. S. Dodds, D. H. Rothman, and J. S. Weitz
Journal of Theoretical Biology, 2001

Times cited: 491
Abstract:
We examine the scaling law B=cMα which connects organismal resting metabolic rate B with organismal mass M, where α is commonly held to be 3/4. Since simple dimensional analysis suggests α=2/3, we consider this to be a null hypothesis testable by empirical studies. We re-analyze data sets for mammals and birds compiled by Heusner, Bennett and Harvey, Bartels, Hemmingsen, Brody, and Kleiber, and find little evidence for rejecting α=2/3 in favor of α=3/4. For mammals, we find a possible breakdown in scaling for larger masses reflected in a systematic increase in α. We also review theoretical justifications of α=3/4 based on dimensional analysis, nutrient-supply networks, and four-dimensional biology. We find that present theories for α=3/4 require assumptions that render them unconvincing for rejecting the null hypothesis that α=2/3.
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BibTeX:
@Article{dodds2001d,
author = {Dodds, Peter Sheridan and Rothman, Daniel H. and Weitz, Joshua S.},
title = {Re-examination of the ``3/4-law'' of metabolism},
journal = {Journal of Theoretical Biology},
year = {2001},
key = {biology},
volume = {209},
pages = {9--27},
}